Hey run whatever you want. A V6 turbo would definitely stand out in a crowd.
There's no doubt that it could be made as good as an LSx with the right amount of time and money. I would just stick to an LSx because are so damn easy (and light)!
If you mount an LSx down low and as far back as you can, you should be able to get real close to 50/50, and keep your CG low.