I'm not sure on the CAD/CAM package that would work the best. Most of the new machines (I think) have some sort of an interface to import certain file types. I have some past experience with ProE and Solidworks. My brother-in-law is a design engineer and is proficient in both. I can tell you that for most things he much prefers Solidworks. In reality for most types of parts, just about any 3D CAD package will suffice. He's is doing some pretty complex surface designs in both ProE and Solidworks.
If you want to talk in more detail about the CAD packages, I could get you in touch with him - he knows his stuff.
Later
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