I did the exact swap your referring about. MSD/FAST Dual Sync/HVC Coil over to the Holley DIS setup using 60-2 trigger, Holley wastespark coils and the 1x Cam Sync from EFI Connection.
The benefits I've seen so far: reduced spark scatter, slightly cleaner looking plugs and the obvious appearance advantage as all my components are mounted out of sight.
Having a 55 Chevy, I was able to mount my coils on the "splash pan" behind the front tire and route the plug wires accordingly. With the wastespark, it does make the plug wire routing abit cumbersome. There are a few good pics on Mike's site for coil mounting ideas.
http://www.eficonnection.com/24x/24x_CoilMount.htm
If you decide to use a distributor, I would recommend using it for the cam sync and running the 60-2 crank trigger to gain the spark accuracy advantage. You can always add coils at another time with this configuration.