You guys should read this. Take the time, you will thank yourself after.
http://www.ar15.com/forums/topic.html?b=1&f=5&t=988015
Its a first hand report of a self defense situation that will get your heart pumping.
I learned quite a few things from that thread. Like how common it is for GSW's to happen in the hands and arms because people focus on the threat of the weapon.
Palm safeties may not work so well if you get shot in the hand and thumb safeties can alert the bad guy.
We all need to train to also shoot one handed with each hand.