Just my .0000000005 cents worth....
Depends on what the final job is - what you're trying to build... a real nice driver - a show car - a riddler contender...
If you're trying to do most of the work yourself - in stages etc.... then degreasing the frame INSIDE and OUT -- maybe a couple of times -- Back in the day I even hooked up the garden hose to the drain hose bib on the hot water heater for a good blast of hot water cleaning with a suitable degreaser. You can also get long WIRE handled brushes - getting a large diameter - and run that in and out of the interior of the frame.
A nice coat or two of SELF ETCHING primer once the steel is all bare....
Or take it to a blaster.... then bring it home and put Self etching primer on it to protect it while you're still mocking up etc. Then paint it once you're happy with everything. It really all depends on your budget and what the end result is planned on. There's about a zillion hot rods out there that have their frames painted with POR 15 and they look great if done right...
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