It's tricky enough that there are people who deal with this stuff for a living. I'm no wizard by any stretch. I have my monitors calibrated "as good as I can" with less than high-end hardware, work from a Pantone book, and 9.5 times out of 10 I get exactly what I want in the final product. The other times I go get me some proofs from a local print shop who knows their ****, make adjustments, take Ibuprofen, repeat.
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