The self-tuning systems like the Fast EZ EFI seem to work well for most people on mild to moderate combo's. Advantage being you don't have to be a tuner to get them to run well. I much prefer laptop tunable systems, but I like to do my own tuning and like being able to swap parts and re-tune down the road. Have had great luck with the Fast systems, and the Accel, BigStuff 3 are also nice. I'm sre the new Holley stuff is very good also, just haven't tuned it yet.
If you are not going to be doing your own tuning then I'd find a local tuner you like and get a recommendation from him. You'll probably want to use a system that he's familiar with. All of them are very capable, just some have more bells and whistles, most of which you won't likely use.
You can run whatever intake/throttle body design you want with these systems, though again if you're not familiar it would be best to get a recommendation from a pro, as some setups are better for some combos than others.
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