I'm only smart enough about MOPARs to know that you've got one he!! of an engine there. I converted my 550 HP Pontiac 462 ci to EFI with little prior knowledge of EFI. Most all of the systems use mid-1990s GM sensors and switches. Most also require a spark box. You need a crank trigger if you go SFI, but there is no more programming or tuning involved with SFI versus batch fire. Sequential will help you get your idle tamed better, especially with a motor that requires big injectors.
I would get a system for which you've got some local expertise available - even if it's a fellow motorhead. I have the Gen7 with wideband and am running sequential.
The majority of my effort went into the layout and physical assembly, especially of the fuel system. I have a bunch of info posted here:
http://www.my67.net/john/efi.htm
and here:
http://www.my67.net/john/Engine%20Progress.htm
I would do your NA motor first, get it right and then worry about the procharged motor. You should be able to run the same basic system, except that you'll need a 3 bar map sensor instead of the single bar. The tune will be very different and less forgiving of errors though.
John