If you have a 6.0 LS, I think 425ish rwhp will be a happy medium. If you start going radical with a cam, and making significantly more power, I think you're going to sacrifice so much torque through the low end and into the mid range that its going to feel slower than a more mild engine.
I also agree with Todd that once you start getting around 650-700 plus, especially in a big cube engine, there simply isn't enough space to really open it up on public roads. I drove my Camaro like a granny around town.
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