In the old days -- cars just used a "road tube"...
The PCV is a "smog issue" where the fumes are recycled and burnt. There really isn't any vacuum created in the crankcase since the opposite valve cover has a filter/breather.
IF -- you run a vacuum pump -- you can get negative crankcase "pressure" and this helps with ring seal but that wasn't your question.
The easiest and best way to handle the crankcase pressure is if you can just use a PCV and breather... it's simple - it's clean - it's effective. But if you can't - then you can use breather/filters in both valve covers and just let the fumes vent to atmosphere. The only reason you'd go to a 'can' is when you're running the car hard and then the breather/filters load up with oil (as it condenses) and the oil starts dripping... Add some fan/wind - and it can blow these small drips all over the place.
The catch cans need to be drained... and the best way is to run the drain right back into the pan if possible so you never have to worry about it. If not that, then remember that you're going to drain the oil out the bottom and that can be messy too! So location becomes an issue.
Some times a guy will forget to drain the can -- and during an event, with running hard and hard cornering etc, a can placed over the top of the headers can blow oil and possibly start a fire at worst, and make a heck of mess at best.