I think the V10 would be pretty cool in an old 50's truck. It'd be fun to toss a SVT Lightning motor/trans in an old F100 too. I'm sure someone's done it, but I can't say I've seen one in person yet.
I would find a Craftsman Truck Series rolling frame or have one built, put the motor in and hang either a 53 Chevy, 55 Chevy or 53 Ford F100 body on it. With that much motor you would want to be 1. Very safe 2. Be able to enjoy all of that power. You could track it, open road race or take it to the drags.
I can;t remember the guys name, but he had a pretty bad ass 55 chevy that he did trackdays with that made a few magazines...but I think it got wrecked. I think that he had either reinforced the stock frame with a cage or had a tube frame built.
I think the motor is too long but putting it in a Pantera would be cool too.
I think a 1970 Fury with a V10 would be killer! A big car with big power. 18x9s up front and 18x12s and a mini tub out back with big meat!!!! Leave the rest of the car stock and lower it just a touch.
I agree with two of the posts above, put it into a big C-body. The big long block will go with the big long car. Fury or Polara will do. Should ride like a dream. Also putting it into an old 40s or 50s Dodge truck would be nice too.