Ty,
I don't claim to be an engine genius, but here's my thoughts.
The turbo is only going to make boost when under a load, so it only works at WOT. It's almost like it's either on or off. So if I'm running down the 1/4 that doesn't matter, because I'm going all out. But on the street or on the track, you will probably prefer some more partial throttle power. Another thing to consider is that on most setups the response seems a little sluggish. From my understanding this is because of all of the plumbing between the turbo and the intake. I'm not talking about turbo lag (because on a really dialed in setup it doesn't have to be there), this is actually an issue of how quickly the system responds to your input.
So I guess I'm just trying to say that your V6 idea would probably create more problems than it's worth. For something different it's kind of cool, but I don't think you could justify it performance wise. And like we all know, its SO EASY to make 500-700hp with an LSx, I don't know why any one would consider anything else.
I don't know the answers to your exhaust questions. I think V2s are usually so friggin' loud and deep because they have practically no exhaust. I don't think that piston size would be the biggest contributor to the "rumble" you are after. I've heard a lot of ford 300's with little to no exhaust, and they just don't have it.
You're probably aware of this already, but you won't be able to get your V6 to sound like a V8. Even if it's throaty, people will think it must have lost two cylinders.