(v)opar all the way
What ya got against the magnum motors? My puny little 408 maggie make over 400 to the wheels on crap CA pump gas, with Iron heads and all that CARB crap to boot. I like the fact they use a roller cam stock and you can run any LA head as well.
A nice build, R3 block, 340 mains with 4" stroke, 4.155 bore, make sure it has the 18 bolt heads. W5 heads (if you can find them) and W5 intake, drilled for EFI. You could make 600hp on pump gas no problem N/A, drop the compression, add a pair of GT42R's and 800 isn't a far stretch
Big blocks are old and busted

and generally way too heavy
If you want something really nasty there was a post on a mopar board where a guy is selling some 358ci pro stock truck motors. R4/P5, top dollar builds for less than those heads cost new.