I'm running one on my 427 SMALL block... can't imagine NOT running one actually - the more crank you have swinging around the more you need some oil control... IMHO
If you already have the basic screen, you should start with that. Like Vegas69 said, you're going to want to make sure it clears. Most rod bolt heads / nuts on 4.25" cranks hit the screen type trays, but they are easily modified.