I'm doing one on Charley's 494 cid Cammer motor with two throttle bodies. No vacuum reference, rear mounted bypass. I am tricking the computer to get it up and running, the base map it builds with the correct cubic inches and fuel pressure is a mile off. Won't even run on 8 cylinders to get to the 140 degrees it needs to start adjusting the tune, and keeps killing plugs.
Looks like it'll work, but in the case of a 13:1 700+ HP solid roller Cammer Ford the XFI would have been a much better choice.............

They say it'll support big power with the two 4-barrel throttle bodies, but then they give you a small 190 LPH pump which I don't think supports their claims. Believe that pump is only good for 450 hp or so, 500 max.