Past 20 years I've been playing with roots, turbo- singles and twins.
Now building twin screw engine with same goal as you.
Only that my starting point is aluminium 572 Hemi custom build for boost and LC 4.2L Kenne Bell. KMS ECU, direct spark coils. European new RE85 fuel/ cont. 85% bioethanol. Should give easily 1000Hp.
You can find my build thread in forced-section.
Twins are good way to make big numbers, maeby most "easiest" to drive, but the heatload they make is big problem. Not if you dont have long WOT times, but use them in road races, bad idea, the hole car will be too hot to touch.
Twin screw is more difficult to drive in the streets, if it is at high HP level, boost comes so fast and so hard.
Nice looking engine by to way