I don't see why you could not do it. Several guys running 295 up front with aftermarket subs (more room on a 69) and as long as you got your rear end width dialed in properly you should be able to make it happen.
Like Ry said, it's been done with 275s and would give you wiggle room.
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2004 NASA AIX Mustang LS2 #14
1964 Lincoln Continental
2014 4 tap Keezer
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